Open AccessThe chemical composition and anti-inflammatory effect of the essential oil obtained from Abeliophyllum distichum flowers
Author(s) -
Ho-Jong Ju,
Heung Bin Lim,
Tae Kyung Hyun
Publication year - 2021
Publication title -
botanica serbica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.19
H-Index - 9
eISSN - 1821-2158
pISSN - 1821-2638
DOI - 10.2298/botserb2101137j
Subject(s) - linalool , essential oil , proinflammatory cytokine , chemistry , lipopolysaccharide , methyl salicylate , chemical composition , gas chromatography–mass spectrometry , botany , anti inflammatory , traditional medicine , food science , chromatography , organic chemistry , biology , mass spectrometry , inflammation , pharmacology , medicine , immunology
In the present study, the chemical composition of the essential oil (EO) obtained from the flowers of Abeliophyllum distichum, commonly known as white forsythia, was examined by gas chromatography-mass spectrometry (GC/MS). Thirty-five components including epoxy linalool, methyl salicylate, linalool oxide (pyranoid), and L-linalool were identified in the EO of A. distichum flowers (AfEO). In addition, the AfEO exhibited a remarkable anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. We found that this anti-inflammatory effect was mediated by inhibiting the expression of proinflammatory mediators, including IL-1?, IL-6, and IL-18. Taken together, these results confirm the potential use of the AfEO as an anti-inflammatory agent for topical application.