Open AccessHas asialoglycoprotein receptor (ASGP-R) a role to play in binding and processing of different parasites?
Author(s) -
Ivona Baričević,
Margita Čuperlović,
Ljiljana Đ. Sofronić-Milosavljević,
Ljiljana M. Vićovac-Panić
Publication year - 2002
Publication title -
acta veterinaria
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.308
H-Index - 17
eISSN - 1820-7448
pISSN - 0567-8315
DOI - 10.2298/avb0206361b
Subject(s) - asialoglycoprotein receptor , endocytosis , in vitro , trichinella spiralis , microbiology and biotechnology , receptor , glycoprotein , biology , chemistry , biochemistry , hepatocyte , immunology , antigen
Liver asialoglycoprotein receptor (ASGP-R), which specifically recognizes and binds galactose and N-acetyl galactosamine, has been implicated in binding and endocytosis of glycoproteins. Therefore, the possibility that it may have a role in contacting and processing pathogenic organisms was investigated. The interaction in vitro between ASGP-R and surface oligosaccharide structures of Echinococcus granulosus and Trichinella spiralis was studied by immunohistochemical methods. Specific binding of ASGP-R to ligands on the surface protoscolex of E. granulosus was demonstrated. To the contrary, ASGP-R bound ligand(s) of T. spiralis stihocytes, while a staining reaction was absent from the parasite cuticle. These results show that ASGP-R could take part in binding to and retention of E. granulosus in liver cells, thus contributing to its hepatotropic activity