Open AccessMolecular mimicry of HIV gp120: Possible implications on prevention and therapy of AIDS
Author(s) -
Nevena Veljković
Publication year - 2005
Publication title -
archive of oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.104
H-Index - 13
eISSN - 1450-9520
pISSN - 0354-7310
DOI - 10.2298/aoo0504126v
Subject(s) - mimicry , molecular mimicry , immune system , human immunodeficiency virus (hiv) , biology , immunology , sequence (biology) , virology , virus , computational biology , genetics , zoology
A broad range of similarities between HIV-1 gp120 and human proteins-especially those participating in immune responses-highlight gp120 as a pleiotropic protein which can influence many important functions of the human immune system. The molecular mimicry that serves to the human immunodeficiency virus as potent destructive arms against immune system could be the weak point we are in search of over decades. Examples involving sequence and informational similarities of HIV-1 gp120 and immunerelated host cell proteins important for prevention and treatment of HIV infection are presented.