Open AccessCFTR F508del mutation and 5T allele in patients with chronic pancreatitis and pancreatic adenocarcinoma
Author(s) -
Aleksandra Nikolić,
Jelena Dinić,
Dragica Radojković,
Snežana Lukić,
D. S. Popović,
Milenko Uglješić,
Srboljub Knezevic
Publication year - 2011
Publication title -
acta chirurgica iugoslavica
Language(s) - English
Resource type - Journals
eISSN - 2406-0887
pISSN - 0354-950X
DOI - 10.2298/aci1103043n
Subject(s) - pancreatitis , medicine , allele , pancreatic cancer , gastroenterology , cystic fibrosis , mutation , hereditary pancreatitis , adenocarcinoma , pancreatic disease , risk factor , pancreas , gene , cancer , genetics , biology , trypsinogen , trypsin , enzyme , biochemistry
Mutations in the CFTR gene may be associated with various types of pancreatic pathology and result in higher risk of pancreatic disorders. While delta F508 is the most common mutation in cystic fibrosis patients, the allel 5T is associated with atypical forms of cystic fibrosis.