Korelacija metabolickih parametara sa promenama intima-medija kompleksa kod gojaznih nedijabeticara i bolesnika sa razlicitim poremecajima glikoregulacije

Measurement of intima-media thickness (IMT) of carotid artery by ultrasound, is well known method. using this noninvasive method in various risks factors such as diabetes mellitus, dislipidemia, hypertension, smoking, age, obesity could be very useful in pathophisiology studies of atherosklerosis. Purpose: The aim of this study was to measure intima media thickness (IMT) of carotid artery, as an early indicator for development of atherosclerosis, and too estimate if there is any significant differences between investigated groups of pts (diabetics pts, pts with glucose intolerance and obese pts without diabetes an older than 45 years). Methods and Materials: 110 pts were divided in five groups: three groups of diabetics pts: type 1 DM (25) pts, type 2 (25) pts and type 2 DM de novo (20), and (20) pts with glucose intolerance, and 20 pts obese without diabetes, older than 45 years of age. Correlation of metabolic parameters ( body mass index (BMI), hip circumference (OS), lipid status) with IMT was performed as well as hypertension, age, sex, smoking and alcohol abuse. Statistics: The authors used 2 test and Spearman's correlation . Results: Intima media ticknes (IMT) was highly statistically significant in grups of DM type 2 and DM tipe 2 de novo. IMT was stat. sig. in pts with high values of BMI and hip circumference according to those pts with normal values. It was also stat. sig. in pts with smoking hiperlipoproteinemia and hypertension. There was no stat. sig. correlation of IMT with sex, age and alcohol abuse. Conclusion: This study showed that diabetics pts have frequent pathological changes on artery vessels and these changes are diffuse and fervently with complicated wall leasens. The influence of these risks factors is very important because their synergetic effects may augment clinical manifestation of atherosclerosis.