Open AccessInfluence of tumor size and intestinal wall invasion on development of colorectal liver metastases
Author(s) -
Andrija Antić,
V. Kalezic,
Dragutin Kecmanović,
Milan Petrović,
Marinko Žuvela,
Slavko Matić,
Maja Pavlov,
Miljan Ćeranić,
Aleksandar Trivić,
Vladan Milović
Publication year - 2008
Publication title -
acta chirurgica iugoslavica
Language(s) - English
Resource type - Journals
eISSN - 2406-0887
pISSN - 0354-950X
DOI - 10.2298/aci0804027a
Subject(s) - medicine , colorectal cancer , prospective cohort study , lymphatic system , lymph node , retrospective cohort study , lymph , gastroenterology , oncology , pathology , cancer
While the general prognostic factors for colorectal carcinoma have been widely researched, the compound relationships between tumor characteristics and development of colorectal liver metastases have not been clearly understood. The aim of this study was to determine which histopathological characteristics of colorectal cancer may be associated with subsequent development of colorectal liver metastases. We performed retrospective and prospective study which included 80 patients operated for colorectal carcinoma on the First Surgical Clinic of Clinical Center of Serbia in Belgrade. Retrospective group consisted of 40 patients operated between 1992. and 1996. while prospective group included 40 patients treated between 1997. and 2001. We analyzed the size of the tumor, depth of invasion through the intestinal wall, extramural spread of the tumor, infiltration of blood vessels and lymphatics, lymph node involvement, tumor maturation and growth, as well circumferential intestinal involvement. Statistical analysis performed showed highly significant (p<0,01) correlation between the tumor size, degree of maturation of the tumor, extramural spread and involvement of the venules with later development of colorectal liver metastases in both groups.