Open AccessThe effects of nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis
Author(s) -
Gordana Stojadinović,
Ljiljana Martać,
Jelena Podgorac,
Slađana Spasić,
Branka Petković,
Slobodan Sekulić,
Srdjan Kesić
Publication year - 2020
Publication title -
archives of biological sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 25
eISSN - 1821-4339
pISSN - 0354-4664
DOI - 10.2298/abs200524036s
Subject(s) - spectral analysis , chemistry , electrophysiology , fractal analysis , neuroscience , neurochemical , fractal dimension , anatomy , fractal , biology , physics , mathematics , quantum mechanics , spectroscopy , mathematical analysis
A detailed analysis of the anesthetic-induced modulation of intracerebellar electrical activity is an important step to understand the functional brain responses to anesthesia. We examined the electrical activity recorded from different cortical layers: molecular layer (ML), Purkinje cell layer (PCL), granular layer (GL) and the white matter (WM) in the vermian part of rat cerebellar lobule V during Nembutal anesthesia using spectral and fractal analysis. Spectral analysis revealed a difference in the mean relative power of delta (0.1-4.0 Hz) and theta (4.1-8.0 Hz) frequencies through the cerebellar layers. Compared to the ML, delta activity increased significantly in the GL, while theta activity decreased in the GL and the WM. Fractal analysis revealed that the mean value of Higuchi?s fractal dimension (HFD) increased, starting from the ML to the WM. Theta activity exhibited a negative correlation with the HFD value in the ML. In contrast, the gamma activity showed a positive correlation with the HFD value in the ML and the GL. The combined use of spectral and fractal analyses revealed that Nembutal displays different effects on rat cerebellar electrical activity, which largely depends on the neurochemical and electrophysiological organization of the cerebellar layers.