Open AccessIdentification and partial characterization of a novel circular transcript of the Tc2n gene from rat mammary gland
Author(s) -
ShiQi Zhu,
Yanhong Wang,
Yanyan Zhao,
Jia Chen,
Chen Chen,
YaMei Jiang,
Jinwei Pang,
Xingtang Fang,
Hong Chen,
Chunlei Zhang
Publication year - 2016
Publication title -
archives of biological sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 25
eISSN - 1821-4339
pISSN - 0354-4664
DOI - 10.2298/abs151015013z
Subject(s) - lactation , mammary gland , biology , uterus , kidney , spleen , medicine , lung , gene expression , endocrinology , ovary , messenger rna , gene , andrology , pregnancy , immunology , genetics , cancer , breast cancer
The regulatory mechanism of mammary gland development and lactation is important, as lactation not only provides healthy milk for infants, but also provides health benefits to mothers. Circular RNAs (circRNAs) have recently received much attention, but only a few have been functionally characterized. In the present study, the structure and expression profile of a rat Tc2n-derived circular RNA (cTc2n) was investigated by several protocols. The cTc2n comprised exons10 and 11 of the Tc2ngeneandhad no poly(A)structure. The expression of cTc2n was significantly higher in the mammary gland of rat than in other tissues, including the heart, liver, spleen, lung, kidney, uterus and ovary. The abundance of cTc2n was the highest on day 1, and significantly declined on day 7, slightly increasing on day 21 postpartum. This finding indicates that cTc2n might play an important role in lactation