Identification and partial characterization of a novel circular transcript of the Tc2n gene from rat mammary gland | Zendy

Zhu Shi | Zendy; Yanhong Wang | Zendy; Yu Zhao | Zendy; Jia Chen | Zendy; Chen Chen | Zendy; Ya Jiang | Zendy; J Jingpang | Zendy; Xing Fang | Zendy; Hong Chen | Zendy; C. Zhang | Zendy

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Identification and partial characterization of a novel circular transcript of the Tc2n gene from rat mammary gland

Author(s) -

Zhu Shi,

Yanhong Wang,

Yu Zhao,

Jia Chen,

Chen Chen,

Ya Jiang,

J Jingpang,

Xing Fang,

Hong Chen,

C. Zhang

Publication year - 2016

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs151015013z

Subject(s) - lactation , mammary gland , biology , uterus , kidney , spleen , medicine , lung , gene expression , endocrinology , ovary , messenger rna , gene , andrology , pregnancy , immunology , genetics , cancer , breast cancer

The regulatory mechanism of mammary gland development and lactation is important, as lactation not only provides healthy milk for infants, but also provides health benefits to mothers. Circular RNAs (circRNAs) have recently received much attention, but only a few have been functionally characterized. In the present study, the structure and expression profile of a rat Tc2n-derived circular RNA (cTc2n) was investigated by several protocols. The cTc2n comprised exons10 and 11 of the Tc2ngeneandhad no poly(A)structure. The expression of cTc2n was significantly higher in the mammary gland of rat than in other tissues, including the heart, liver, spleen, lung, kidney, uterus and ovary. The abundance of cTc2n was the highest on day 1, and significantly declined on day 7, slightly increasing on day 21 postpartum. This finding indicates that cTc2n might play an important role in lactation

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