Open AccessIdiopathic sudden hearing loss: Oxidative status before and after corticoid treatment
Author(s) -
Bogdan D. Cavaleriu,
D Mârţu,
Lucian Hrițcu,
Oana R. Manolache,
Luminiţa Rădulescu
Publication year - 2015
Publication title -
archives of biological sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 25
eISSN - 1821-4339
pISSN - 0354-4664
DOI - 10.2298/abs150909106c
Subject(s) - malondialdehyde , glutathione peroxidase , oxidative stress , superoxide dismutase , lipid peroxidation , antioxidant , medicine , endocrinology , chemistry , biochemistry
The aim of this study was to investigate antioxidant enzyme activities and lipid peroxidation levels after systemic corticoid therapy (Solu-Medrol, 250mg/day, for 7 days). The effects of corticoid treatment on superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity were investigated. Fifteen patients diagnosed with sudden sensorineural hearing loss were enrolled. Serum markers of oxidative stress were measured using spectrophotometric methods. In ten cases, the SOD and GPX activities and malondialdehyde (MDA) serum levels before and after corticoid treatment were investigated. Corticoid treatment enhanced antioxidant activity by increasing SOD and GPX activities and decreasing MDA serum levels