Open AccessThe roles of p38mAPK and caspase-3 in dads-induced apoptosis in human HepG2 cells
Author(s) -
Chunxiao Ji,
Heng Ma,
Ren Feng-lian
Publication year - 2010
Publication title -
archives of biological sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 25
eISSN - 1821-4339
pISSN - 0354-4664
DOI - 10.2298/abs1002245c
Subject(s) - apoptosis , microbiology and biotechnology , caspase , caspase 3 , chemistry , caspase 8 , biology , programmed cell death , biochemistry
The roles of p38MAPK and caspase-3 in DADS-induced apoptosis in human HepG2 cells were investigated. After the human HepG2 cells were treated with DADS, the cell viability, apoptosis and the activity changes of p38MAPK and caspase-3 were measured. The results indicated that DADS can activate p38MAPK and caspase-3. The results showed that p38MAPK and caspase-3 are involved in the process of DADS-induced apoptosis in human HepG2 cells and interact with each other