Open AccessRetinoic acid-induced SoX3 gene expression in NT2/D1 cells is RXR homodimer-independent
Author(s) -
Tijana Savić,
Milena Stevanović,
Gordaikčević
Publication year - 2009
Publication title -
archives of biological sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 25
eISSN - 1821-4339
pISSN - 0354-4664
DOI - 10.2298/abs0904631s
Subject(s) - retinoic acid , retinoid x receptor , biology , retinoid , microbiology and biotechnology , gene , gene expression , receptor , regulation of gene expression , genetics , transcription factor , nuclear receptor
The Sox3/SOX3 gene is implicated in the control of nervous system development. We previously demonstrated modulation of human SOX3 gene expression during neural induction of NT2/D1 cells by retinoic acid (RA). Also, we accurately verified RXR retinoid receptors as major mediators of the effect of RA on SOX3 expression, and excluded RARs as its heterodimeric partners in RA-SOX3 signaling. Here we present evidence that activation of the SOX3 gene by RA is not RXR homodimer-dependent. The described line of SOX3 gene expression studies is valuable for future investigation of the impact that this gene has multiple aspects of normal and pathological development