Open AccessExpression of prolactin receptors in the human extra villous cytotrophoblast cell line HTR-8/SVNEO
Author(s) -
Ivana Stefanoska,
Ljiljana Vićovac
Publication year - 2008
Publication title -
archives of biological sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.217
H-Index - 25
eISSN - 1821-4339
pISSN - 0354-4664
DOI - 10.2298/abs0804519s
Subject(s) - cytotrophoblast , prolactin , receptor , immunocytochemistry , biology , trophoblast , microbiology and biotechnology , prolactin receptor , medicine , cell culture , endocrinology , endometrium , western blot , hormone , placenta , fetus , pregnancy , genetics , gene
Prolactin is a pituitary hormone that is widely produced at extrapitutitary locations. One of the first described sites of its production is the decidualized endometrium, suggesting that it could be potentially significant for local processes such as immunomodulation, embryo implantation, and survival. In this study, expression of prolactin receptor protein is investigated by immunocytochemistry and Western blot in the HTR-8/SVneo cell line, often used as a model of first-trimester trophoblast. The obtained data enabled us to identify both long and intermediate forms of prolactin receptors, which were shown to be significant in PRL signaling in other tissues