Open AccessPrenatal antibiotic therapy as a risk factor for Neonatal Necrotizing Enterocolitis
Author(s) -
Л. Г. Бочкова,
А. С. Эйберман,
Yu. V. Chernenkov,
О. К. Кирилочев
Publication year - 2021
Publication title -
detskie infekcii
Language(s) - English
Resource type - Journals
eISSN - 2618-8139
pISSN - 2072-8107
DOI - 10.22627/2072-8107-2021-20-2-33-37
Subject(s) - medicine , necrotizing enterocolitis , odds ratio , incidence (geometry) , pediatrics , low birth weight , logistic regression , risk factor , retrospective cohort study , birth weight , case control study , ampicillin , obstetrics , antibiotics , pregnancy , physics , microbiology and biotechnology , biology , optics , genetics
The aim of this study was to determine whether there is an association between antenatal antibi-otic exposure and the incidence of necrotizing enterocolitis (NEC) in low birth weight infants. Study design : A retrospective case-control study was conducted on all infants with NEC who were born between 201 0 and 2020. Medical histories of all infants diagnosed with NEC ≥ Bella IIA stage and corresponding controls without NEC were examined. Maternal and newborn char-acteristics were compared using the Cochran-Mantel-Haenszel method, and logistic regression models were constructed to account for bias. Results. Clinical data were analyzed for 97 matched pairs. The adjusted odds ratio (OR) for pre-natal ampicillin exposure was significantly higher for infants who developed NEC (OR 2.3, 95% CI 1.1,4.8, P = 0.003) than for children in the control group. Infants who developed NEC were more likely to have a history of intrauterine exposure to ampicillin in the immediate prenatal period than infants who did not develop NEC.