Open AccessClinical observation of Сhronic granulomatous disease in a 6-year-old child
Author(s) -
Г. А. Харченко,
О. Г. Кимирилова
Publication year - 2020
Publication title -
detskie infekcii
Language(s) - English
Resource type - Journals
eISSN - 2618-8139
pISSN - 2072-8107
DOI - 10.22627/2072-8107-2020-19-4-69-72
Subject(s) - chronic granulomatous disease , medicine , pneumonia , disease , sepsis , hematopoietic stem cell transplantation , meningitis , phagocytosis , pathology , immunology , pediatrics
Chronic granulomatous disease (CGD) is a hereditary disease caused by a genetic defect of violations of oxygen — dependent mechanisms of phagocytosis. Clinical manifestations of the disease are recurrent bacterial or fungal infections of the skin, hepatic abscesses, pneumonia, osteomyelitis, sepsis, meningitis et al. Most available laboratory method for the diagnosis of CGD is the test of histochemical nitro blue tetrazolium recovery (NBT-test). Allogeneic hematopoietic stem cell transplantation is considered a radical treatment for chronic granulomatous disease. The article presents a clinical observation of the manifestation of chronic granulomatous disease with an unfavorable outcome in a child aged 6 years.