Open AccessOPTIMIZATION OF DIAGNOSIS OF CYTOMEGALOVIRUS INFECTION IN YOUNG CHILDREN
Author(s) -
A. V. Permyakova,
Н. С. Поспелова,
I I Lvova
Publication year - 2018
Publication title -
detskie infekcii
Language(s) - English
Resource type - Journals
eISSN - 2618-8139
pISSN - 2072-8107
DOI - 10.22627/2072-8107-2018-17-3-51-56
Subject(s) - saliva , cytomegalovirus , polymerase chain reaction , urine , viral load , medicine , virology , cytomegalovirus infection , virus , human cytomegalovirus , immunology , dna , biology , herpesviridae , viral disease , gene , genetics
The results of a laboratory examination of 520 children aged 1—3 years are presented. The examination was conducted to determine the DNA of cytomegalovirus in children with acute cytomegalovirus infection in various biological media by polymerase chain reaction. The differences in the virus shedding into the blood, saliva, and urine are established: the median of the viral load for saliva is 4.9 lg copies of DNA/ml, the blood 3.4 lg copies of DNA/ml, urine — 3.85 lg copies of DNA/ml. The cut of extreme values of the viral load are determined with the help of mathematical modeling which determine the clinical probability of developing acute CMV infection which allows for more accurate and timely assignment of etiotropic therapy.