Open AccessEnteric viral hepatitis in the Socialist Republic of Vietnam (Southern Vietnam)
Author(s) -
Yu. V. Ostankova,
А. В. Семенов,
Д. Э. Валутите,
Е. Б. Зуева,
Е. Н. Серикова,
А. Н. Щемелев,
Hoang Khanh Thu Huynh,
Е. В. Эсауленко,
Арег А. Тотолян
Publication year - 2021
Publication title -
žurnal infektologii
Language(s) - English
Resource type - Journals
eISSN - 2499-9865
pISSN - 2072-6732
DOI - 10.22625/2072-6732-2021-13-4-72-78
Subject(s) - viral hepatitis , serology , hepatitis e virus , medicine , hepatitis a , virology , antibody , hepatitis e , immunology , hepatitis , population , biology , genotype , environmental health , biochemistry , gene
Aim : To study the hepatitis A (HAV) and hepatitis Е (HEV) prevalence in the Southern region of Vietnam based on the frequency analysis of the antibodies to hepatitis A and E viruses detection in the local population and groups at increased risk of infection. Materials and methods . Serological markers of enteral viral hepatitis were determined in blood serum samples from adults aged 18 to 65 years of three groups: conditionally healthy individuals (n = 397), HIV-infected (n = 316), and patients with chronic viral hepatitis (n = 268). The ELISA method was used for the qualitative detection of anti-HAV IgG, anti-HAV IgM, anti-HEV IgG, anti-HEV IgM. Results . When analyzing the prevalence of anti-HAV IgG in samples obtained from conditionally healthy, HIV-infected, and patients with chronic viral hepatitis, no differences were found between the groups. The incidence of anti-HAV IgG in the general group (n = 981) was 80.1%, in the absence of anti-HAV IgM. There were no gender-age differences in the frequency of anti-HAV IgG in the examined groups. Antibodies anti-HEV IgG in the groups of conditionally healthy, patients with chronic viral hepatitis, and HIV-infected were present in the samples in 36,2%, 33,2%, and 39,8% of cases, respectively. The prevalence of anti-HEV IgM in these groups was 3,27%, 4,1%, and 3,79%, respectively. In the general group (n = 981), anti-HEV IgG was detected in 36,6% of cases, anti-HEV IgM in 3,66%, which corresponds to the prevalence of antibodies to HEV in endemic regions. Conclusion . A high incidence of enteral viral hepatitis markers was shown in residents of South Vietnam, including the groups of conditionally healthy, patients with chronic viral hepatitis, and HIV-infected. There is an obvious need for further studies of the spread extent of hepatitis A and hepatitis E in the Socialist Republic of Vietnam using currently available highly sensitive diagnostic methods, including sequencing of the virus›s nucleotide sequences.