Open AccessAntimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata
Author(s) -
Gracielle Oliveira Sabbag Cunha,
Ana Paula Terezan,
Andréia Pereira Matos,
Marcela Carmen de Melo Burger,
Paulo Cézar Vieira,
João B. Fernandes,
Maria Fátima das Graças Fernandes da Silva,
Antônio Carlos Severo Menezes
Publication year - 2020
Publication title -
acta brasiliensis
Language(s) - English
Resource type - Journals
eISSN - 2526-4338
pISSN - 2526-432X
DOI - 10.22571/2526-4338249
Subject(s) - antimicrobial , staphylococcus aureus , bacillus subtilis , candida albicans , ursolic acid , escherichia coli , pseudomonas aeruginosa , microbiology and biotechnology , terpene , biology , chemistry , biochemistry , bacteria , botany , genetics , gene
This study evaluated the antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata (Melastomataceae) against five microorganisms: Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 6623), Pseudomonas aeruginosa (ATCC 15442), and Candida albicans (ATCC 10231). The isomeric mixture of ursolic and oleanolic acids was active against S. aureus (MIC = 250 μg mL-1) and against E. coli, B. subtilis, and P. aeruginosa (MIC = 500 μg mL-1). The flavone 5,6,7-trihydroxy-4’-methoxyflavone and the methyl esters, semisynthetic derivatives of a mixture of ursolic and oleanolic acids, showed no activity against the tested microorganisms. These results suggest that the carboxyl group present in the triterpenes may contribute to antimicrobial activity.