Open AccessThe molecular mechanisms linking metabolic syndrome to endometrial and breast cancers
Author(s) -
Andrada-Luciana Lazăr,
Romana Vulturar,
Adriana Fodor,
Olga Hilda Orăşan,
Camil-Horia Eusebiu Crișan,
Cezar Login,
Ioana Para,
Vasile Negrean,
Brînduşa Tiperciuc,
Angela Cozma
Publication year - 2021
Publication title -
journal of mind and medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2601-4920
pISSN - 2392-7674
DOI - 10.22543/7674.82.p167178
Subject(s) - medicine , metabolic syndrome , hyperinsulinemia , endometrial cancer , adipokine , dyslipidemia , insulin resistance , breast cancer , obesity , cancer , oncology , bioinformatics , endocrinology , biology
The metabolic syndrome represents a plethora of cardio-metabolic risk factors including obesity, arterial hypertension, atherogenic dyslipidemia, hyperglycemia, accompanied by pro-inflammatory and pro-thrombotic state. The metabolic syndrome is one of the key risk factors for certain types of cancer. Among these malignancies, breast cancer and endometrial neoplasms require special attention. Incriminated major causes for the development of breast and endometrial cancer in metabolic syndrome patients are: the proinflammatory status and related cytokines, adipokine imbalances, hyperestrogenism, growth factors, disturbances in cancer microenvironment, insulin resistance and hyperinsulinemia. The metabolic syndrome consists of molecular dysregulations that create a pro-oncogenic status. Our review aims at providing a better understanding of the mechanisms underlying the link between the metabolic syndrome and endometrial and breast cancer.