Open AccessA mini-review regarding the carcinogenesis and morphology of serous tumors of the ovary, fallopian tube and peritoneum
Author(s) -
Tiberiu-Augustin Georgescu,
Roxana Elena Bohîlţea,
Octavian Munteanu,
Corina Grigoriu,
Ioana Păunică,
Maria Sajin
Publication year - 2021
Publication title -
journal of mind and medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2601-4920
pISSN - 2392-7674
DOI - 10.22543/7674.81.p4452
Subject(s) - serous carcinoma , fallopian tube , serous fluid , medicine , peritoneum , pathology , serous membrane , serous cystadenoma , ovary , ovarian cancer , cancer , gynecology
Similar to the already well-recognized adenoma-carcinoma sequence in colorectal cancer pathogenesis, it has been believed for many decades that the progression of ovarian epithelial tumors occurs from benign serous cystadenomas to borderline tumors, to well-differentiated carcinomas, and ultimately, to poorly differentiated carcinomas. However, it is currently accepted that low-grade serous carcinoma (LGSC) and high-grade serous carcinoma (HGSC) are fundamentally different tumor types and, consequently, different diseases. In fact, whereas the benign-borderline-malignant sequence seems to apply quite well to low-grade serous carcinoma, the sequence of genetic alterations in high-grade serous carcinoma is substantially different. In this mini-review, we included the current consensus regarding the morphological and etiopathogenic results regarding serous tumors of the ovary, fallopian tube and peritoneum. It also briefly describes the history of benign, borderline and malignant serous tumors, discussing multiple types of dichotomies in serous carcinomas of the female genital tract and summarizing the current molecular classification.