Open AccessEffect of blocking i kur on the genesis of action potential alternans in canine atrium
Author(s) -
Na Zhao,
Qince Li,
Kuanquan Wang,
Runnan He,
Yongfeng Yuan,
Henggui Zhang
Publication year - 2020
Publication title -
2019 computing in cardiology (cinc)
Language(s) - English
Resource type - Conference proceedings
SCImago Journal Rank - 0.257
H-Index - 55
ISSN - 2325-887X
ISBN - 978-1-7281-6936-1
DOI - 10.22489/cinc.2019.124
Subject(s) - bioengineering , computing and processing , signal processing and analysis
The Kv1.5 channel-mediated, ultra-rapid delayed rectifier K + current (I Kur ) is a promising target for anti-arrhythmic drugs due to its ‘atrial-selective’ property. However, it is unclear yet if blocking I Kur can increase the alternans susceptibility in normal atria.This study aimed to investigate the effect of blocking I Kur on the genesis of AP alternans associated with arrhythmogenesis. The updated canine atrial cell model developed by Ramirez et al. was used to implement the dynamic pacing protocol and the standard S1-S2 protocol to obtain rate dependent curves and restitution curves of AP duration (APD) and Ca 2+ transient which were further analyzed for the alternans susceptibility.Simulation results showed the prolonged AP and increased Ca 2+ transient (CaT) by blocking I Kur . I Kur block from 40% to 80% produced long-short-long-short APD and Ca 2+ transient alternans at pacing rate of ~ 2.3 Hz to 5 Hz. Further analysis showed that a possible mechanism for generating the observed alternans was due to the elevated plateau phase of AP by blocking I Kur , which modulated APD and CaT via I CaL . Our findings demonstrate that blocking I Kur may promote the genesis of APD and CaT alternans, implying a latent pro-arrhythmic effect in normal atria.