Open AccessSecondary metabolites, letalithy and antimicrobial activity of six marine sponges from Mochima Bay, Sucre state, Venezuela.
Author(s) -
Raúl Cedeño Ramos,
Haydelba D ́Armas,
María Amaro,
Rosa Martínez
Publication year - 2015
Publication title -
cuadernos de investigación uned/cuadernos de investigación uned
Language(s) - English
Resource type - Journals
eISSN - 1659-4266
pISSN - 1659-441X
DOI - 10.22458/urj.v7i2.1149
Subject(s) - artemia salina , sponge , brine shrimp , antimicrobial , ethyl acetate , antibacterial activity , biology , staphylococcus aureus , microbiology and biotechnology , traditional medicine , chemistry , bacteria , botany , biochemistry , ecology , organic chemistry , toxicity , medicine , genetics
he specimens of the sponges Aplysina lacunosa, Aplysina fulva, Cliona varians, Cinachyrella kuekenthali, Amphimedon viridis and Aaptos pernucleata, were collected in Mochima Bay, Venezuela, in October 2009 with the purpose of identifying families of secondary metabolites and evaluating the antibacterial properties, antifungal and brine shrimp lethal study of the ethyl acetate soluble fractions of these sponges. The chemical evaluation showed the presence of alkaloids, sterols, triterpenes, methylene ketone and tannins. The ethyl acetate soluble fractions of A. pernucleata, A. fulva and A. lacunosa sponges were the only ones that showed antibacterial activity against Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli; the soluble fraction of A. lacunosa showed the highest inhibition zones. The antifungal activity was not significant, except for A. pernucleata sponge wich showed mild activity against Candida albicans. The most prominent lethal activity in Artemia salina, were observed for C. kuekenthali, A. viridis and A. pernucleata sponges, with LC50 values of 4,10, 1,13 and < 0,01µg/mL respectively. These results allow profiling the sponges A. lacunosa, A. pernucleata and A. fulva as promising sources of antimicrobial compounds and the sponges C. kuekenthali, A. viridis and A. pernucleata as sources of antitumor compounds.