Open AccessDifferential diagnosis between oral fibroma and inflammatory hyperplasia: a proposal for histopathological criteria
Author(s) -
Cristiano Macabú Badauy,
Vinícius Coelho Carrard,
Thaíse Gomes E Nóbrega,
Felipe Nör,
Márcia Gaiger de Oliveira,
Manoel Sant’Ana Filho
Publication year - 2013
Publication title -
revista da faculdade de odontologia de porto alegre
Language(s) - English
Resource type - Journals
eISSN - 2177-0018
pISSN - 0566-1854
DOI - 10.22456/2177-0018.50379
Subject(s) - h&e stain , pathology , trichrome , medicine , differential diagnosis , fibroma , hyperplasia , histopathology , pathological , lesion , staining
Oral Fibroma and Inflammatory Hyperplasia display similarities in their clinical and histopathological appearance. The present study proposed histopathological criteria for the differential diagnosis between those pathological entities. Histological sections of lesions histopathologically diagnosed as Oral Fibroma (n=61) and Inflammatory Hyperplasia (n=75) and were submitted to different techniques (Hematoxylin-Eosin; Masson Trichrome and Phosphomolybdic acid - Picrosirius red) to allow quantitative and qualitative analysis. The qualitative analysis of collagen density was based on sections stained by Hematoxylin-Eosin and focused in the center and periphery of each lesion. Wound and collagen fibers were more frequent and higher in Oral Fibroma, while parallel fibers were more frequent in Inflammatory Hyperplasia (Fisher’s exact test, p