Open AccessThe mechanisms of osteoclastic activity: literature review
Author(s) -
Ângelo Barbosa de Resende,
Luciano Barreto Silva,
Carolina dos Santos Guimarães,
Rosana Maria Coelho Travassos,
Ana Paula Veras Sobral
Publication year - 2010
Publication title -
revista da faculdade de odontologia de porto alegre
Language(s) - English
Resource type - Journals
eISSN - 2177-0018
pISSN - 0566-1854
DOI - 10.22456/2177-0018.20517
Subject(s) - bone resorption , microbiology and biotechnology , homeostasis , haematopoiesis , immune system , osteoclast , osteoimmunology , bone tissue , bone cell , chemistry , bone matrix , cell , matrix (chemical analysis) , immunology , neuroscience , biology , medicine , pathology , stem cell , anatomy , endocrinology , biochemistry , in vitro , chromatography , activator (genetics) , gene , rankl , cartilage
Bone tissues are continually being remodeled depending on the organic situation, with hard tissue resorption and neoformation. Homeostasis and inflammatory conditions concerning bone may bring about the activation of hematopoietic cells with the ability to generate or dissolve bone matrix for a number of organic needs. The mechanisms used by osteoclasts to resorb hard tissues and the basic cell to cell interactions, with the participation of immune cells such as lymphocytes, along with other substances, as well as bone composition are described in this review.