Open AccessAvaliação de soluções antifúngicas de guanidina para resina base de dentadura: um estudo in vitro
Author(s) -
Maria Eduarda Rodrigues Gama,
Vicente Castelo Branco Leitune,
Isadora Martini García,
Stéfani Becker Rodrigues,
Fabrício Mezzomo Collares
Publication year - 2020
Publication title -
revista da faculdade de odontologia de porto alegre
Language(s) - English
Resource type - Journals
eISSN - 2177-0018
pISSN - 0566-1854
DOI - 10.22456/2177-0018.104096
Subject(s) - distilled water , acrylic resin , flexural strength , nuclear chemistry , candida albicans , antifungal , chemistry , materials science , surface roughness , composite material , chromatography , microbiology and biotechnology , biology , coating
Background: The purposes of this study were: (1) to formulate polyhexamethylene guanidine hydrochloride (PHMGH) solutions at different concentrations; (2) to evaluate their antifungal activity against a mature biofilm of Candida albicans on acrylic resins; (3) to evaluate possible effects on acrylic resins flexural strength and surface roughness. Methods: PHMGH solutions were formulated with distilled water and 0.125, 0.250, or 0.5 wt.% of PHMGH. One group without PHMGH was used as control. For antifungal activity analysis, acrylic resin specimens were contaminated with C. albicans. Specimens were immersed in PHMGH solutions or distilled water for 5 or 10 min. Ultimate flexural strength and surface roughness of acrylic resins were evaluated. Results: All PHMGH solutions at 5 or 10 min showed antifungal activity compared to the control group (p