Open AccessHepatic Microhaemocirculation Dynamics in Experimental Extrahepatic Cholestasis
Author(s) -
Kh. K. Akhmedov,
М. А. Эргашев,
А. Н. Мелибобоев,
Э. Х. Болтаев
Publication year - 2020
Publication title -
rossijskij žurnal gastroènterologii, gepatologii, koloproktologii
Language(s) - English
Resource type - Journals
eISSN - 2658-6673
pISSN - 1382-4376
DOI - 10.22416/1382-4376-2020-30-6-45-50
Subject(s) - cholestasis , parenchyma , medicine , pathology , ligation , bile duct , peripheral , gastroenterology
Aim . Investigation of hepatic microhaemocirculation eects in experimental extrahepatic cholestasis. Materials and Methods . Experiments were carried out with a mixed group of 48 white mongrel male rats. Extrahepatic cholestasis was modelled in rats with via the ligation of common bile duct. Results . Animals with ligated common bile duct showed abnormalities in peripheral hepatic circulation manifested by a complex of intravascular, vascular and paravascular changes, hepatic angioarchitectonics disturbance, a marked growth of parenchymal dystrophic lesions in the form of post-haemorrhagic foci. The disturbance was pronounced towards a virtual degradation of hepatic parenchyma and the growth of “numb” zones with ceased circulation. Conclusion . The trials revealed microcirculatory changes in the liver associated with rheological disturbance of blood and, subsequently, the toxic impact of failed metabolism.