Open AccessMutual Effect of <i>NAT2</i> rs1799930 (590G>A) Polymorphism and Alcohol Abuse on Risk of Acute Pancreatitis
Author(s) -
Т. А. Самгина
Publication year - 2020
Publication title -
rossijskij žurnal gastroènterologii, gepatologii, koloproktologii
Language(s) - English
Resource type - Journals
eISSN - 2658-6673
pISSN - 1382-4376
DOI - 10.22416/1382-4376-2020-30-6-40-44
Subject(s) - acute pancreatitis , odds ratio , gastroenterology , genotyping , medicine , pancreatitis , alcohol consumption , allele , alcohol , ethanol , polymorphism (computer science) , genotype , alcohol abuse , taqman , biology , gene , genetics , polymerase chain reaction , biochemistry , psychiatry
Aim . Estimation of the contribution of rs1799930 (590G>A) polymorphism of gene NAT2 to the development of acute alcoholic pancreatitis. Materials and methods . DNA samples were obtained from 547 unrelated patients with acute alcoholic pancreatitis and 573 unrelated individuals without gastrointestinal diseases. A survey selected individuals with the alcohol consumption of >200 g/week pure ethanol two times a week or more during 10 or more years. Genotyping was performed with PCR using TaqMan allelic discrimination assays. Results . No association was observed between the NAT2 allelic rs1799930 (590G>A) polymorphism, risk of acute alcoholic pancreatitis, duration and rate of alcohol consumption. The 590G>A variant of rs1799930 in gene NAT2 correlated with an increased risk of acute alcoholic pancreatitis (odds ratio 2.16; 95% condence interval 1.13–4.12) under alcohol consumption >200 g/week pure ethanol. Conclusion . The rs1799930 G/A polymorphism of gene NAT2 increases the risk of acute pancreatitis under alcohol consumption >200 g/week pure ethanol.