Open AccessClinical Traits of SARS-CoV-2 Infection
Author(s) -
O. Yu. Zolnikova,
Н. Л. Джахая,
Н. Д. Поцхверашвили,
Kirill Puzakov,
Olga I. Kiseleva,
Н. И. Кокина,
Э. Р. Буклис,
Т. В. Рощина,
Inna Komkova
Publication year - 2020
Publication title -
rossijskij žurnal gastroènterologii, gepatologii, koloproktologii
Language(s) - English
Resource type - Journals
eISSN - 2658-6673
pISSN - 1382-4376
DOI - 10.22416/1382-4376-2020-30-6-28-39
Subject(s) - medicine , concomitant , gastroenterology , diabetes mellitus , hepatology , ferritin , lymphocyte , covid-19 , disease , infectious disease (medical specialty) , endocrinology
Aim . Analysis of clinical manifestations, laboratory and instrumental examination data in SARS-CoV-2 patients with taking into account the disease severity and outcome. Materials and methods . The study included 92 patients with conrmed coronavirus infection, including 15 lethal cases, hospitalised at the Vasilenko Clinic of Internal Disease Propaedeutics, Gastroenterology and Hepatology of the Sechenov University in April 2020. The analysis included demographic data, the presence of concomitant diseases, chest computed tomography (CT) results, laboratory tests (including SARS-CoV-2-diagnostic PCR, general and metabolic blood panels, coagulogram) and the duration of disease. Results . Patients infected with SARS-CoV-2 usually exhibit lymphopenia (p ≤ 0.001), leucocytosis, the elevated neutrophils ( p ≤ 0.05), neutrophil-lymphocyte ratio (p ≤0,05), C-reactive protein ( p ≤ 0.05), ferritin ( p ≤ 0.05), D-dimer ( p ≤ 0.05) and brinogen ( p ≤ 0.05), altered prothrombin time ( p ≤ 0.05) and INR ( p ≤ 0.05). In a critical coronavirus infection, the pulmonary lesion exceeds 50% (corresponds to CT3 — CT4). The risk of critical SARS-CoV-2 infection increases with elder age (p ≤ 0.001), associates with the male gender and presence of concomitant diseases, such as obesity ( p < 0.01), diabetes mellitus ( p < 0.001), hypertension ( p ≤ 0.001), CHD ( p ≤ 0.001) and atrial brillation ( p <0.05). Conclusion . The risk of severe and adverse coronavirus infection is signicantly higher in elder comorbid patients.