Refractory Hypercalcemia in a Jamaican Woman | Zendy

Amaris Balitsky MSc | Zendy; Jonathan So | Zendy; MSc Carolyn Chessex | Zendy

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Refractory Hypercalcemia in a Jamaican Woman

Author(s) -

Amaris Balitsky MSc,

Jonathan So,

MSc Carolyn Chessex

Publication year - 1970

Publication title -

canadian journal of general internal medicine

Language(s) - English

Resource type - Journals

eISSN - 2369-1778

pISSN - 1911-1606

DOI - 10.22374/cjgim.v11i1.119

Subject(s) - medicine , refractory (planetary science) , differential diagnosis , malignancy , methotrexate , gastroenterology , hyperparathyroidism , lymphoma , pathology , physics , astrobiology

The two common differential diagnoses for hypercalcemia are malignancy and hyperparathyroidism. In this case of a young woman with hypercalcemia refractory to bisphosphonate treatment, Vitamin D and parathyroid hormone releasing peptide (PTHrP) levels were normal. She was found to be positive for HTLV-1 and later diagnosed with Adult T-cell leukaemia/ lymphoma, with CNS involvement. After treatment with R-CHOP therapy with intrathecal methotrexate, her symptoms improved and her calcium returned to normal. The differential diagnosis and treatment of hypercalcemia is further discussed.

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