Open AccessA Streptococcus Intermedius Brain Abscess Causing Obstructive Hydrocephalus and Meningoventriculitis in an Adult Patient With Chronic Granulomatous Disease
Author(s) -
Fareed Kamar,
FRCPC Vinay Dhingra
Publication year - 1970
Publication title -
canadian journal of general internal medicine
Language(s) - English
Resource type - Journals
eISSN - 2369-1778
pISSN - 1911-1606
DOI - 10.22374/cjgim.v10i2.35
Subject(s) - chronic granulomatous disease , medicine , hydrocephalus , brain abscess , streptococcus intermedius , immunodeficiency , abscess , population , immunology , streptococcus , streptococcus pneumoniae , pathology , antibiotics , surgery , microbiology and biotechnology , immune system , bacteria , biology , environmental health , genetics
An inherited abnormality of phagocytosis, chronic granulomatous disease (CGD), represents an immunodeficiency characterized by recurrent infection and granuloma formation due to a genetic defect in NADPH oxidase. The 36-year-old male patient with CGD described in this case featured a brain abscess due to Streptococcus intermedius infection, complicated by meningoventriculitis and obstructive hydrocephalus. His condition was managed with broad-spectrum antibiotics, interferon gamma-1b, and bilateral external ventricular drains. This report addresses a particular paucity in the literature involving Streptococcus intermedius central nervous system infection in the adult CGD population.