Open AccessOptimizing Platelet-Rich Plasma (PRP) Injections: A Narrative Review
Author(s) -
Chris Cherian,
Gerard A. Malanga,
Kenneth Mautner
Publication year - 2020
Publication title -
biologic orthopedic journal
Language(s) - English
Resource type - Journals
ISSN - 2766-9777
DOI - 10.22374/boj.v2i1.11
Subject(s) - platelet rich plasma , growth factor , platelet , vascular endothelial growth factor , platelet derived growth factor receptor , platelet derived growth factor , medicine , clarity , transforming growth factor , narrative review , vegf receptors , immunology , biology , intensive care medicine , biochemistry , receptor
Platelet-rich plasma (PRP) is an orthobiologic treatment that has gained popularity as a potential alternative treatment for various musculoskeletal conditions. The physiologic role of platelets in the healing cascade provides clarity regarding its potential as it releases various growth factors such as platelet-derived growth factor (PDGF), transforming growth factor beta-1 (TGF-β1), and vascular endothelial growth factor (VEGF). However, there are various characteristics of PRP treatments including platelet count, presence or absence of leukocytes and red blood cells, as well as the use of an activating agent that introduces heterogeneity among preparations. This aim of this article is to provide clarity, where available, regarding the optimal characteristics for PRP treatments regarding tendon and ligament injuries as well as articular and muscular pathology.