Open AccessChanges in Serum Levels of Growth Factors in Chronic Gastritis
Author(s) -
Л. В. Матвеева,
Л. В. Матвеева,
Л. М. Мосина,
Л. М. Мосина,
М. А. Стенина,
М. А. Стенина
Publication year - 2019
Publication title -
vestnik rossijskogo universiteta družby narodov. seriâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2313-0261
pISSN - 2313-0245
DOI - 10.22363/2313-0245-2019-23-3-250-256
Subject(s) - medicine , exacerbation , chronic gastritis , gastritis , gastroenterology , atrophic gastritis , atrophy , vascular endothelial growth factor , esophagogastroduodenoscopy , gastric mucosa , helicobacter pylori , pathology , immunology , stomach , endoscopy , vegf receptors
Chronic inflammation, contributing to atrophy of the gastric epithelium, can develop in the induction of Helicobacter pylori and other microorganisms secretion of cytokines by cells of the gastric mucosa, including growth factors. Violation of the processes of repair of the gastric mucosa in terms of immune and microbiotic imbalance is the basis of ulcer and carcinogenesis. The aim of the study was to determine the serum level and diagnostic value of growth factors in exacerbation of chronic gastritis. Materials and methods . With informed consent in 122 patients with exacerbation of chronic gastritis and 40 healthy volunteers, sampling of gastrobioptates with esophagogastroduodenoscopy (for histological and microbiological examination), 5 ml of venous blood with serum separation (for enzyme immunoassay of serum levels of growth factors) was performed. Results . The amount of granulocyte-macrophage colony stimulating factor, erythropoietin, vascular endothelial growth factor (VEGF) in the serum of patients with atrophic gastritis exceeded the values of healthy individuals, were directly related to the degree and stage of gastritis, Helicobacter pylori infection, and among themselves. The greatest diagnostic value in atrophy gastric epithelial was determined in VEGF (sensitivity - 95,9%, specificity - 48,98%, criterion more 225 pg/ml, AUC 0,654, p = 0,0072). Conclusion. Determination of serum growth factors, especially VEGF, with exacerbation of chronic gastritis is diagnostically valuable, should be used for early diagnosis of atrophy of the gastric epithelium.