Open AccessStructural changes in rats organism in experimental intoxication with herbicide 2,4-DA
Author(s) -
S.M. Shakirova,
G.R. Shakirova,
Biotechnology named after K.I. Skryabin
Publication year - 2016
Publication title -
vestnik rossijskogo universiteta družby narodov. seriâ agronomiâ i životnovodstvo
Language(s) - English
Resource type - Journals
eISSN - 2312-7988
pISSN - 2312-797X
DOI - 10.22363/2312-797x-2016-3-57-64
Subject(s) - parenchyma , pathology , infiltration (hvac) , lymph , lung , necrosis , toxicity , anatomy , chemistry , biology , medicine , physics , thermodynamics
In subacute toxicity herbicide 2,4-DA LD50, in the macroscopic examination of organs in rats set changes inherent poisoning by toxic substances. Heart muscle and kidneys flabby, uneven coloring. Lung red-pink color with areas of acute atelectasis. By light and electron microscopy, we found that the herbicide 2,4-DA has polytropic effect on experimental animals. In the myocardium revealed foci of necrosis where cardiomyocytes have fuzzy outlines and poor color. Structural changes are accompanied by an increase in the number of infiltration of lymphocytes and macrophages. In the kidneys due to necrotic and degenerative changes in the tubules of nephrons organ's parenchyma becomes grayish color. In the walls of medium and small bronchi of lung localized massive lymphocytic infiltration. The interalveolar septum tissue greatly expanded due to the large number of white blood cells. In all investigated organs disorders found blood and lymph circulation.