Lipofuscin: a key compound in ophthalmic practice | Zendy

Edward Florian Călin | Zendy; Stella Ioana Popescu | Zendy; Corina Cernat | Zendy; Cristina Patoni | Zendy; M. Popescu | Zendy; Ovidiu Mușat | Zendy

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Lipofuscin: a key compound in ophthalmic practice

Author(s) -

Edward Florian Călin,

Stella Ioana Popescu,

Corina Cernat,

Cristina Patoni,

M. Popescu,

Ovidiu Mușat

Publication year - 2021

Publication title -

romanian journal of ophthalmology

Language(s) - English

Resource type - Journals

eISSN - 2501-2533

pISSN - 2457-4325

DOI - 10.22336/rjo.2021.23

Subject(s) - lipofuscin , autofluorescence , retinal pigment epithelium , retinal , fluorophore , pigment , chemistry , retina , pathology , biochemistry , fluorescence , biology , microbiology and biotechnology , medicine , neuroscience , physics , organic chemistry , quantum mechanics

Lipofuscin is an intracellular aging pigment with fluorescent properties, found in retinal pigment epithelium cells of the eye. It is the main fluorophore used in fundus autofluorescence imaging techniques to diagnose, describe, and follow retinal disease. Lipofuscin forms by incomplete lysosomal degradation of cellular material previously subjected to oxidative changes. A2E is the most studied fluorescent component of lipofuscin, but most of its composition remains unknown. Lipofuscin is photoreactive, generating reactive oxygen species, which may explain its role in disease development. Further knowledge is needed concerning lipofuscin genesis, biochemical composition, fluorescent compounds, and role in pathogenesis of retinal degenerative disease.

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