Open AccessThe effect of prenatal hypoxia on the manifestation of the ventilatory reaction of Wistar rats upon presentation of a hypoxic stimulus
Author(s) -
A. N. Vjotosh,
О. С. Алексеева,
A. I. Istomin
Publication year - 2022
Publication title -
morskaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2587-7828
pISSN - 2413-5747
DOI - 10.22328/2413-5747-2022-8-1-89-93
Subject(s) - gestation , hypoxia (environmental) , offspring , plethysmograph , respiration , pregnancy , medicine , respiratory system , physiology , anesthesia , endocrinology , biology , oxygen , chemistry , anatomy , genetics , organic chemistry
The aim of the scientific work was to study the multidirectional effect of hypoxic sessions presented to pregnant rats at different periods of gestation on the manifestation of the ventilatory reaction of their offspring with dosed hypoxic hypoxia. Materials and methods : a plethysmograph were used to record respiratory volume, respiratory rate and calculate the minute volume of respiration of intact rats (n=77) of the Wistar breed. Results and discussion : presentation of a hypoxic stimulus to pregnant rats on certain days of gestation did not affect the gestation period, body weight and number of offspring, but changed the ventilatory response to hypoxia in males born and reached three months of age. Prenatal hypoxia, presented in the middle of pregnancy, led to a decrease in the ventilatory response to lack of oxygen in the offspring, and exposure of pregnant rats in hypoxic conditions at the end of the second trimester increased the ventilatory response to hypoxia.