Open AccessOptions of neurovascularization in patients with type 2 diabetes mellitus using different methods of magnetic resonance perfusion
Author(s) -
Ю. Г. Самойлова,
М.В. Матвеева,
О. С. Тонких,
O. P. Leuman,
Olga Gerget
Publication year - 2021
Publication title -
lučevaâ diagnostika i terapiâ
Language(s) - English
Resource type - Journals
eISSN - 2079-5351
pISSN - 2079-5343
DOI - 10.22328/2079-5343-2021-12-1-36-48
Subject(s) - medicine , magnetic resonance imaging , diabetes mellitus , body mass index , cardiology , microcirculation , hypoglycemia , perfusion , glycemic , type 1 diabetes , contrast (vision) , type 2 diabetes , radiology , endocrinology , artificial intelligence , computer science
Objective . To evaluate neurovascularization using contrast and non-contrast magnetic resonance perfusion. Materials and methods . 140 patients with type 2 diabetes with and without cognitive impairment were included in the study. We assessed the variability of glycemia, magnetic resonance imaging (MRI): contrast and non-contrast. Results : brain neurovascularization change is associated with glycemia variability, with contrast advantage revealed in the contrast study. Microcirculation disorder occurs in both cortical (grey matter area) and subcortical structures. The greatest influence on brain vascularization disturbance in type 2 diabetes was revealed in terms of age, body mass index, arterial hypertension. Hyperglycemia and its duration, as well as hypoglycemia, control quality, average amplitude of oscillation, average time in the target range determined the change of vascularization. Conclusions . Understanding the pathogenesis of microcirculation disorders and the role of glycemia variability in the brain in type 2 diabetes, it is possible to correct the glycemic curve in time and eliminate modifiable risk factors (body mass index, arterial hypertension) affecting the development of cognitive disorders.