Open AccessPossibilities of small-size glioblastoma visualization by PET-CT with 11C-choline (experimental study)
Author(s) -
Н. А. Костеников,
V. F. Dubrovskaya,
Е. Г. Кованько,
O. Yu. Mirolyubova,
Yu. R. Ilyushchenko,
A. A. Stanzhevsky
Publication year - 2021
Publication title -
lučevaâ diagnostika i terapiâ
Language(s) - English
Resource type - Journals
eISSN - 2079-5351
pISSN - 2079-5343
DOI - 10.22328/2079-5343-2020-11-4-30-36
Subject(s) - glioblastoma , choline , glioma , positron emission tomography , nuclear medicine , medicine , magnetic resonance imaging , radiology , cancer research
. The minimum size of malignant brain tumors detected by positron emission and computed tomography (PET-CT) exceeds 6-7 mm. One of the ways to increase the sensitivity of PET-CT in detecting of malignant brain tumors is to increase the administered activity of the radiopharmaceutical 11C-choline. Purpose & tasks . The aim of the study was to experimentally study the possibility of obtaining a small-size glioblastoma (GB) images (up to 4 mm) by PET-CT with the 11C-choline. Materials and methods . The study was performed on 24 rats with implanted intracerebral tumor «Glioma C6» (glioblastoma). Animals underwent magnetic resonance imaging (MRI) with contrast enhancement (CE) and PET-CT with 11C-choline for 21 days after tumor transplantation. Results . It was shown that using two methods: MRI with CE and PET-CT with 11C-choline, a glioblastoma up to 4 mm can be convincingly visualized. Conclusion . The data obtained can be crucial for early detection of glioblastoma, justification of treatment tactics, evaluation of the treatment effectiveness and prediction the outcome of the disease.