Open AccessThe state of intestinal microflora in patients with cirrhosis of the liver of viral etiology and the correction of its treatment
Author(s) -
М. Д. Ахмедова,
G. Yu. Sultonova,
A. M.-T. Bektimirov,
А. Н. Баринова
Publication year - 2021
Publication title -
vič-infekciâ i immunosupressii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.176
H-Index - 4
eISSN - 2078-1792
pISSN - 2077-9828
DOI - 10.22328/2077-9828-2021-13-1-97-105
Subject(s) - etiology , cirrhosis , medicine , dysbiosis , viral hepatitis , gastroenterology , concomitant , disease , probiotic , hepatitis , liver disease , immunology , biology , bacteria , genetics
The objective: to study the state of intestinal microflora in patients with cirrhosis of the liver of viral etiology and pathogenetic substantiate therapeutic measures taking into account the severity of the disease, the period of therapy. Materials and research methods. This study was conducted on the basis of the clinic RIEMID MH RUz in the department of chronic viral hepatitis. To achieve this goal and solve problems, we examined 35 patients with a diagnosis of CP of viral etiology (all patients were with a delta agent), the average age of the patients was 38±9,7 years. Men 20 (57%), women 15 (43%). Groups of patients were selected by random sampling as they were admitted to the hospital. Results and discussion. Summarizing the data obtained, it should be emphasized that in patients with CP of viral etiology, the progression of the disease is accompanied by the parallel progression of a violation of microbiocenosis. The formation of dysbiosis and aggravation of the degree of dysbiosis is directly dependent on the amount of concomitant pathology. That is, the more concomitant pathology, the higher the likelihood of the formation of intestinal dysbiosis. During a clinical examination, intestinal dysbiosis was found in all 35 (100%) patients. Conclusions. Cirrhosis of the liver is accompanied by functional changes in the colon, which increase as the class of cirrhosis increases. The use of the probiotic Bactrimsubtil normalized the intestinal microflora in patients with LC, helping to reduce the manifestation of a number of clinical symptoms.