Open AccessHumoral immunity to SARS-CoV-2 among the population of Murmansk region amid COVID-19 epidemic
Author(s) -
А. Yu. Popova,
Е. Б. Ежлова,
А. А. Мельникова,
Л А Лукичева,
N. I. Nikitina,
L. V. Lyalina,
В. С. Смирнов,
N. S. Koltsov,
M. V. Ermakova,
A. K. Kubashev,
V. V. Kuznetsova,
Tamara Denisova,
N. V. Gurina,
I. V. Ziborov,
I. V. Gryazova,
N. A. Pankova,
P. I. Konoshkin,
N. I. Mikheeva,
Alena A. Sharova,
Арег А. Тотолян
Publication year - 2021
Publication title -
vič-infekciâ i immunosupressii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.176
H-Index - 4
eISSN - 2078-1792
pISSN - 2077-9828
DOI - 10.22328/2077-9828-2021-13-1-17-27
Subject(s) - seroprevalence , herd immunity , population , incidence (geometry) , immunity , covid-19 , veterinary medicine , demography , antibody , geography , immunology , medicine , serology , environmental health , immune system , mathematics , geometry , disease , sociology , infectious disease (medical specialty)
Purpose of the study. Determination of the level and structure of population immunity to SARS-CoV-2 among the population of the Murmansk region against the background of the incidence of COVID-19. Materials and methods. The study was carried out according to a unified method for determining the seroprevalence of the population, developed by Rospotrebnadzor with the participation of the St. Petersburg Pasteur Institute. A total of 3117 volunteers were examined, distributed into 7 age groups. The content of antibodies to SARS-CoV-2 was determined by ELISA using a set of reagents for analyzing human serum or plasma for the presence of specific immunoglobulins of class G to the nucleocapsid of the SARS-CoV-2 virus produced by the FBUN GNCPMiB Rospotrebnadzor (Obolensk) in accordance with the instructions for application. Results. The level of population immunity in the Murmansk region as a whole was 31,2%. The highest seroprevalence was found among children aged 1–6 and 7–13 years (35.6% and 44,1%, respectively), the lowest among the elderly population aged 60–69, as well as 70 and more years (20,4% and 20,9%, respectively). In the cities of the Murmansk region. the herd level of immunity varied from 19,6% (Kola city) to 46,1% (Kandalaksha city). It was not possible to find a reliable relationship between the incidence of the population of the cities of the Murmansk region and seroprevalence. The highest level of seroprevalence was noted among office workers (38,0%), the lowest among transport workers (19,5%). In the presence of contacts with patients with COVID-19, seropositivity increased 1,4 times compared to the average population value. The level of specific humoral immunity in convalescents after COVID-19 is 64,1%, which is 2,2 times higher than the average for half-day. The proportion of asymptomatic forms among seroprevalence volunteers was 89%.