Open AccessАnalysis of cases of progressive multifocal leukethephalopathy in patients with HIV infection: clinical, epidemiological, diagnostic and therapeutic aspects of the problem
Author(s) -
A. B. Konkova-Reidman,
T. V. Mikheeva,
A. A. Veksey,
Н. В. Смирнова,
Yu. Y. Ermolenko,
M. V. Radzikhovskaya
Publication year - 2021
Publication title -
vič-infekciâ i immunosupressii
Language(s) - English
Resource type - Journals
eISSN - 2078-1792
pISSN - 2077-9828
DOI - 10.22328/2077-9828-2020-12-4-81-86
Subject(s) - medicine , progressive multifocal leukoencephalopathy , epidemiology , human immunodeficiency virus (hiv) , christian ministry , jc virus , viral load , pediatrics , immunology , virus , philosophy , theology
Purpose of research . Study of epidemiological, clinical, diagnostic and therapeutic features of progressive multifocal leukoencephalopathy in HIV-infected patients. Materials and methods . We analyzed 10 cases of deaths from PML of patients with HIV infection according to the reports of the Magnitogorsk AIDS Center for 2014–2016, and provided our own clinical observation of a patient with PML who was treated in 1 infectious Department of the South Ural State Medical University of the Ministry of Health of Russia in 2018 year. Results and discussion . In most cases of PML observed with CD4+ less than 50 cells and a viral load of more than 150 000 HIV RNA copies/ml, brain MRI is an informative method of in vivo diagnosis, WARTH slows the progression and improves the prognosis of patients.