Open AccessBLOOD OF CYTOKINE LEVELS AND THEIR CORRELATIONS WITH LIVER INJURY IN PATIENTS COINFECTED WITH HIV AND HEPATITIS C VIRUS
Author(s) -
Л. Б. Королевская,
Е. В. Сайдакова,
K. V. Shmagel
Publication year - 2019
Publication title -
vič-infekciâ i immunosupressii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.176
H-Index - 4
eISSN - 2078-1792
pISSN - 2077-9828
DOI - 10.22328/2077-9828-2019-11-3-57-63
Subject(s) - proinflammatory cytokine , medicine , hepatitis c virus , liver injury , immunology , gastroenterology , cytokine , inflammation , human immunodeficiency virus (hiv) , hepatitis c , virus
The aim of the study was to evaluate the levels of blood of cytokines and their correlations with indices of liver injury in patients coinfected with HIV and hepatitis C virus. Materials and methods . 61 persons were enrolled in the study: HIV/VHC coinfected patients (n=20), HIV monoinfected patients (n=21) and non-infected volunteers (n=20). Serum levels of IL-6, IL-10, IL-5, TNF-a, VEGF, FGF basic and biomarkers of liver injury (AST, SGPT, APRI) were measured. The significant increase in serum levels of proinflammatory and anti-inflammatory cytokines in HIV/VHC co-infected patients compared to the same indices in HIV mono-infected patients was detected. Positive correlation between biomarkers of liver injury and concentrations of observed cytokines and growth factors was found. Conclusion. In chronic inflammation, increased level of peripheral proinflammatory and anti-inflammatory cytokines and their associations with biomarkers of liver injury may explain accelerated liver fibrosis in HIV/HCV coinfected patients.