Open AccessPULMONARY TB WITH CONCOMITANT MYCOBACTERIOSIS IN PATIENTS WITH LATE-STAGE HIV INFECTION
Author(s) -
В. Ю. Мишин,
А. В. Мишина,
Atadzhan Ergeshov,
Vladimir Romanov,
Aleksandr L. Sobkin
Publication year - 2019
Publication title -
vič-infekciâ i immunosupressii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.176
H-Index - 4
eISSN - 2078-1792
pISSN - 2077-9828
DOI - 10.22328/2077-9828-2019-11-2-34-41
Subject(s) - concomitant , medicine , tuberculosis , stage (stratigraphy) , nontuberculous mycobacteria , human immunodeficiency virus (hiv) , lung , radiological weapon , immunology , pathology , mycobacterium , surgery , biology , paleontology
We studied social status, clinical and radiological manifestations, microbiological and immunological peculiarities in 26 latestage HIV infection patients with pulmonary TB and concomitant mycobacteriosis. They all had CD4+ lymphocyte counts less than 30 cells/μL of blood, did not receive antiretroviral therapy, and excreted both M. tuberculosis and nontuberculous mycobacteria (NTM). Identification of NTM species was based on molecular genetic methods. We found M. avium complex in 84,6%, M. kansasii — in 7,7%, M. fortuitum — in 3,8% and M. xenopi — in 3,8% of the patients. The disease manifested 6–9 years after diagnosing HIV infection; it had pronounced intoxication syndrome, bronchopulmonary and extrapulmonary presentations and was accompanied by other opportunistic infections. Radiological studies revealed intrathoracic adenopathy, dissemination with predominant localization in the middle and lower lung departments, foci and small infiltrates with cavities; injury of interlobar and visceral pleura.