Open AccessA study of the Incidence of Cytomegalovirus infection and Preemptive Therapy in Kidney Transplant Recipients
Author(s) -
Zana Sidiq M. Saleem,
Kais Harzallah,
Nashwan Ibrahim,
Nawfal R Hussein,
Hasanain MA Al-Khammas
Publication year - 2022
Publication title -
journal of contemporary medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2415-1629
pISSN - 2413-0516
DOI - 10.22317/jcms.v8i1.1125
Subject(s) - medicine , incidence (geometry) , cytomegalovirus , cytomegalovirus infection , renal transplant , prospective cohort study , kidney transplantation , cohort , kidney transplant , transplantation , immunology , human cytomegalovirus , herpesviridae , viral disease , human immunodeficiency virus (hiv) , virus , physics , optics
Objectives: This project aimed to determine the incidence of CVM infection and evaluate the outcome of preemptive treatment.Methods: This prospective, two centers cohort study included recipients who underwent renal transplant between May 2019-May 2020. The incidence of CMV infection and graft outcomes were studied. All managed with preemptive therapy.Results: In this study, 134 renal transplant recipients were recruited. Among them, 30/134 (22.4%) patients tested positive for CMV-RTPCR. We studied the impact of age on the CMV-positivity and we found that the age of the doner was associated with CMV-positivity (P= 0.025; OR= 0.923; CI= 0.8584-0.9943). Smoking and gender showed no association with CMV-positivity.Conclusions: our data suggest that the course of CMV infection is benign with a high success rate of preemptive treatment. Further evaluation for the universal prophylactic plan is needed.