Open AccessCystatin-C in patients with acute coronary syndrome: Correlation with ventricular dysfunction, and affected coronary vessels
Author(s) -
Dhulfiqar Ali Abed,
Raad Jasim,
Hayder Abdul-Amir Makki Al-Hindy,
Ammar Waheeb Obaid
Publication year - 2020
Publication title -
journal of contemporary medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2415-1629
pISSN - 2413-0516
DOI - 10.22317/jcms.v6i1.729
Subject(s) - ejection fraction , creatinine , medicine , cystatin c , uric acid , renal function , cardiology , acute coronary syndrome , coronary arteries , heart failure , artery , myocardial infarction
Objective: This study designed to inspect the circulating levels of Cy/C in patients with ACS and to evaluate the association of Cy/C levels with ejection fraction and angiographic number of stenosed coronaries. Methods: 136 participants with ACS were enrolled in this case-control survey and compared with 94 control. Hematological assessments were done for all the participants and included Cy/C, creatinine and uric acid were measured using conventional technique. Creatinine clearance rate was calculated and Estimated glomerular-filtration-rate (eGFR) were measured. Echocardiographic assessment of ejection fraction was done with a cut-off-point 70% decrease in caliber). Results: Ejection fraction was significantly lower in in ACS patients than control group (p 0.05) observed between groups. The eGFR were significantly lower in ACS people compared to healthy persons. Correlation studies of Cy/C showed positive correlation with serum creatinine and serum uric acid; as well as non-significant negative correlation with eGFR (p>0.05). Conclusion: Besides the role of Cy/C in early detection of renal dysfunction, it could have a role in diagnosis of ACS and evaluation of LV systolic dysfunction. Nevertheless, this study showed Cy/C was not related to the number of coronary arteries affected.