Nephroprotective effect of Curcumin (Curcuma Longa) in acute nephrotoxicity in Sprague-Dawley rats | Zendy

Hayder M. Alkuraishy | Zendy; Ali I. AlGareeb | Zendy; Huda Abdulbaki Rasheed | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Nephroprotective effect of Curcumin (Curcuma Longa) in acute nephrotoxicity in Sprague-Dawley rats

Author(s) -

Hayder M. Alkuraishy,

Ali I. AlGareeb,

Huda Abdulbaki Rasheed

Publication year - 2019

Publication title -

journal of contemporary medical sciences

Language(s) - English

Resource type - Journals

eISSN - 2415-1629

pISSN - 2413-0516

DOI - 10.22317/jcms.v5i2.580

Subject(s) - nephrotoxicity , gentamicin , creatinine , curcumin , malondialdehyde , pharmacology , blood urea nitrogen , oxidative stress , curcuma , distilled water , kidney , medicine , chemistry , antibiotics , traditional medicine , biochemistry , chromatography

Objective: The objective of the present study was to evaluate the nephroprotective effect of curcumin in gentamicin induced-nephrotoxicity. Methods: Thirty Male Sprague-Dawley rats were used which divided into three groups, Group1 (n=10): Rats treated with distilled water plus normal saline for 12 days. Group2 (n=10): Rats treated with distilled water plus gentamicin for 12 days. Group 3(n=10): Rats treated with curcumin plus Gentamicin for 12 days. Blood urea, serum creatinine, malondialdehyde (MDA), kidney injury molecule (KIM-1) and cystatin-c were measured in both control and experimental groups. Results: Rats treated with gentamicin showed nephrotoxicity as evidence by significant elevation in serum creatinine, blood urea, KIM-1, MDA, Cystatin-C sera levels. Conclusion: Curcumin produced significant nephroprotective effect in gentamicin induced-nephrotoxicity through modulation of oxidative stress and inflammatory biomarkers.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research