Open AccessNephroprotective effect of Curcumin (Curcuma Longa) in acute nephrotoxicity in Sprague-Dawley rats
Author(s) -
Hayder M Al-Kuraishy,
Ali I. AlGareeb,
Huda A Rasheed
Publication year - 2019
Publication title -
journal of contemporary medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2415-1629
pISSN - 2413-0516
DOI - 10.22317/jcms.v5i2.580
Subject(s) - nephrotoxicity , gentamicin , creatinine , curcumin , malondialdehyde , pharmacology , blood urea nitrogen , oxidative stress , curcuma , distilled water , kidney , medicine , chemistry , antibiotics , traditional medicine , biochemistry , chromatography
Objective: The objective of the present study was to evaluate the nephroprotective effect of curcumin in gentamicin induced-nephrotoxicity. Methods: Thirty Male Sprague-Dawley rats were used which divided into three groups, Group1 (n=10): Rats treated with distilled water plus normal saline for 12 days. Group2 (n=10): Rats treated with distilled water plus gentamicin for 12 days. Group 3(n=10): Rats treated with curcumin plus Gentamicin for 12 days. Blood urea, serum creatinine, malondialdehyde (MDA), kidney injury molecule (KIM-1) and cystatin-c were measured in both control and experimental groups. Results: Rats treated with gentamicin showed nephrotoxicity as evidence by significant elevation in serum creatinine, blood urea, KIM-1, MDA, Cystatin-C sera levels. Conclusion: Curcumin produced significant nephroprotective effect in gentamicin induced-nephrotoxicity through modulation of oxidative stress and inflammatory biomarkers.