Open AccessPrognostic value of serum creatinine in traumatic brain injury
Author(s) -
Ana Maria Mendes Ferreira,
Jakeline Silva Santos,
Alysson Alves Marim,
Tiago Domingos Teixeira Rincon,
Kaio Henrique Viana Gomes,
Guilherme Perez de Oliveira,
Eduardo de Sousa Martins e Silva,
Tamires Hortêncio Alvarenga,
Gabriella Gomes Lopes Prata,
João Pedro de Oliveira,
Fernando Henrique dos Reis Sousa,
Thiago Silva Paresoto,
Daniel Del Nero Casselli,
Luiz Fernando Alves Pereira,
Gustavo Branquinho Alberto,
Lívia Grimaldi Abud Fujita,
Murillo Martins Correia,
Roberto Alexandre Dezena
Publication year - 2021
Publication title -
jornal brasileiro de neurocirurgia
Language(s) - English
Resource type - Journals
eISSN - 2446-6786
pISSN - 0103-5118
DOI - 10.22290/jbnc.v32i3.1976
Subject(s) - creatinine , medicine , traumatic brain injury , logistic regression , retrospective cohort study , glasgow coma scale , surgery , psychiatry
Introdution: Traumatic brain injury (TBI) is a complex event, plenty of populational and regional peculiarities, with multiple causes and different levels of severity, having a wide range of prognosis. Objectives: To present and identify the prognostic association of serum creatinine dosage at admission of TBI patients in the Triângulo Mineiro region, Brazil. Methods: Quantitative, retrospective and documental study based on the analysis of medical records of TBI patients presented at the Clinics Hospital of Federal University of Triângulo Mineiro in the city of Uberaba, Brazil, from January 2007 to December 2017. Results: A total of 794 TBI patients were included. The mean value of serum creatinine was higher in males with severe TBI, altered CT, subdural hematoma, brain swelling, pneumocephalus, and death outcome, and with increasing values the higher the age range. Serum creatinine was also independently associated with the death outcome (after adjustment through multivariate logistic regression) (CR: 1.64; CI: 1.25-2.15). The serum creatinine value of 1.18 mg/dL represented the cutoff point of best specificity (89.12%; CI: 86.4-91.5) and sensitivity (42.13%; CI: 34.8- 49.7). Conclusions: Serum creatinine was independently associated with the death outcome, proving to be a promising laboratory predictor of TBI.