Open AccessSudep: risk factors, protective factors and pathophysiological mechanisms
Author(s) -
Louise Ferreira Krol,
Beatriz Chiquito Sacchi,
Paulo Henrique Pires de Aguiar
Publication year - 2021
Publication title -
jornal brasileiro de neurocirurgia
Language(s) - English
Resource type - Journals
eISSN - 2446-6786
pISSN - 0103-5118
DOI - 10.22290/jbnc.v32i2.1963
Subject(s) - epilepsy , pathophysiology , cardiorespiratory fitness , medicine , risk factor , intensive care medicine , pediatrics , psychiatry
Sudden Unexpected Death In Epilepsy (SUDEP) is the main cause of premature death in patients with epilepsy. The pathophysiology is not clear, however there are risks and protective factors described in the literature. Objective: To gather the data of these variables and elucidate the pathophysiological mechanisms. Methods: Literature review of free full articles from PubMed database from 2000 to 2019, in English, with an impact factor higher than 1, carried out in humans. As keywords were used “SUDEP”; “Epilepsy”; “Sudden Death”; “Seizure” resulting in 130 articles, and 44 reflecting the objectives. Results: A total of 11 case control and 10 cohort studies was analyzed and the risks and protective factors were presented. Among the risks were found: nocturnal seizure, frequencies, young adults, generalized tonic-clonic (GTCS) type and others. Some of protective factors were adherence to treatment, night supervision and having pets. Discussion: There are evidences that cardiorespiratory and autonomic systems interfere on the phisiopatology. Conclusion: More studies are necessary to elucidate all the involved mechanisms.