SILICA IODIDE CATALYZED ULTRASOUND ASSISTED ONE-POT THREE-COMPONENT SYNTHESIS OF 3,4-DIHYDROPYRIMIDINE-2-(1H)-ONES/-THIONES

Aim and objective: A single-pot three-component reaction for a competent preparation of biologically active 3,4-dihydropyrimidineones/-thiones using Silica Iodide (SiO2-I) as a reliable and reusable heterogeneous catalyst is developed. Methods: The reaction proceeds via condensation of araldehydes, urea/thiourea, ethyl acetoacetate in ethanol under ultrasonic condition to afford the target molecules in best yields. The reaction proceeds in 30 min and SiO2-I has shown high proficiency in performing this single-pot Biginelli reaction. Results: The use of catalytic SiO2–I (0.1 g) accelerated the reaction and gave the product in excellent yield. Maximum yield of the product was found to be 96% in ethanol Conclusion: Study concludes the used method has shown many advantages, mild condition, short duration, simple isolation and best yields of products. Peer Review History: Received: 10 September 2021; Revised: 18 October; Accepted: 02 October, Available online: 15 November 2021 Academic Editor:  Ahmad Najib, Universitas Muslim Indonesia,  Indones UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:   Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye Dr. Sunita Singh, Baylor College of Medicine, Houston, Texas, USA, sunita.nccs@gmail.com Idoko Alexander, Caritas University, Enugu, Nigeria, idokoalexander1@gmail.com Similar Articles: GREEN, RAPID, SIMPLE, AND AN EFFECTIVE ONE-POT MULTICOMPONENT STRATEGY FOR SYNTHESIS OF NOVEL DIHYDROPYRANO[2,3-C]PYRAZOL-6-AMINES IN AQUEOUS MEDIUM