MODULATORY EFFECT OF HARMINE ON SPATIAL MEMORY, FERTILITY VIA MAO INHIBITION, PREVENTING ANEMIA AND ANTI-NOCICEPTION UPON FOOTSHOCK STRESS AT THREE STAGES OF PREGNANT RATS

Aim and objective: Stress has overwhelmed the world, mortality due to stress is continually increasing, and pregnancy has known by its physiological modulation. This article has a clear explanation about the effect of the ß-carboline alkaloid harmine containing in the plant of Peganum harmala, it makes a huge debate in many countries as Iran, Brazil, Algeria, China, Australia about the main component that exerted abortion and until now there is no work resolved the matter. Methods: In this study, we planned our experience, so that each sub-group treated with harmine, stressed with footshock or received the both, according to their pregnancy stages. Results: Footshock stress as expected with its maximum intensity could be tolerated by the fetuses so could keep the rats pregnant along the main stage, damaged to several physiological parameters, but it makes a good pairing with harmine. Conclusion: Harmine has enhanced the cognition during pregnancy, and exerted its anxiolytic effect too. Its decreasing effect of food consumption and enhancement of implantation was the main reason to confirm its raising estrogen levels from previous works, raising thrombocytes due to its enhancement of serotonin via its effect of monoamine-oxydase inhibitor MAO I. In other hand, footshock stress even its expected placentation defect but it seemed having an ameliorating effect on immune function during pregnancy. Peer Review History: Received: 8 September 2021; Revised: 11 October; Accepted: 26 October, Available online: 15 November 2021 Academic Editor:  Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt, gehankandeel9@yahoo.com  UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:   Reviewer's Comments: Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com Dr. Muhammad Zahid Iqbal, AIMST University, Malaysia, drmmziqbal@gmail.com Dr. Vanina Doris Edo’o, University of Yaounde I, Yaounde, Cameroun, vanina_edoo@yahoo.com Similar Articles: EFFECT OF THE AQUEOUS EXTRACT OF CLERODENDRUM THOMSONIAE LINN (VERBENACEAE) LEAVES ON TYPE 2 DIABETIC WISTAR RATS INDUCED BY THE MACAPOS1 TYPE DIET AND DEXAMETHASONE MYOCARDIAL POTENCY OF AQUEOUS EXTRACT OF HARUNGANA MADAGASCARIENSIS STEM BARK AGAINST ISOPROTERENOL-INDUCED MYOCARDIAL DAMAGE IN RATS