Open AccessHEPATOPROTECTIVE ACTIVITY OF ASPARGUS RACEMOSUS ROOT EXTRACT ON LIPOPOLYSACCHARIDE INDUCED OXIDATIVE STRESS IN RATS
Author(s) -
Mohammad Ahmad,
Tarannum Perween,
Smita Singh,
Ragni Sinha,
Arshad Hussain,
Shadma Wahab,
Awadhesh Kumar Jha
Publication year - 2019
Publication title -
universal journal of pharmaceutical research
Language(s) - English
Resource type - Journals
ISSN - 2456-8058
DOI - 10.22270/ujpr.v4i1.232
Subject(s) - malondialdehyde , oxidative stress , aspartate transaminase , superoxide dismutase , glutathione , chemistry , lipopolysaccharide , alanine transaminase , nitric oxide , pharmacology , asparagus racemosus , liver function , catalase , biochemistry , medicine , endocrinology , alkaline phosphatase , traditional medicine , enzyme , medicinal plants
Lipopolysaccharide (endotoxin) produces an inflammatory condition leading to multiple organ failure. LPS most potent bacterial products is used for induction of host oxidative stress responses and liver injury. Present study was undertaken to investigate the effect of Asparagus racemosus Willd. root extract in lipopolysaccharide (LPS) induced oxidative stress in rats by measuring oxidative stress markers, nitric oxide, liver function test and cytokines. The obtained data showed that LPS administration significantly reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT), total cholesterol (TC) and albumin (ALB). There was significant increase in malondialdehyde (MDA), cytokines activity, serum aspartate transaminase(AST), alanine transaminase(ALT), alkaline phosphate (ALP), total bilirubin (TB) and nitric oxide(NO). The methanolic extract of Asparagus racemosus (MEAR) administration significantly (P<0.05) reduced LPS-induced oxidative stress by normalizing liver GSH, SOD, CAT, MDA, NO, cytokines and liver function markers. MEAR significantly increased ALB and TC level. Our results suggest that MEAR protects the liver against liver toxicity induced by LPS.