Open AccessSYNTHESIS AND MOLECULAR DOCKING ANALYSIS OF OXAZETIDINE DERIVATIVES FOR NEUROLOGICAL DISORDERS
Author(s) -
O.G. Bhusnure
Publication year - 2021
Publication title -
journal of medical pharmaceutical and allied sciences
Language(s) - English
Resource type - Journals
ISSN - 2320-7418
DOI - 10.22270/jmpas.v10i4.1768
Subject(s) - propanoic acid , chemistry , docking (animal) , adenosine receptor , spectral analysis , tryptophan , molecule , adenosine , stereochemistry , receptor , amino acid , combinatorial chemistry , biochemistry , organic chemistry , spectroscopy , medicine , agonist , nursing , physics , quantum mechanics
A series of Oxazetidine (NL1-NL12) from reacting tryptophan and aromatic aldehydes were synthesized in good yields by involving 2-{[(4-chlorophenyl) methylidene] amino}-3-(1H-indol-3-yl) propanoic acid and chloro acetyl chloride as reactive intermediates. All the synthesized derivatives were screened via spectral techniques. Synthesized molecules were virtually screened against Human A2A Adenosine receptor interactions analysis using molecular docking to elucidate CNS potential. Synthesized derivatives showed excellent binding towards the Human A2A Adenosine receptor.